In the present investigation, new antimicrobial agents, arylimidazo [2,1-b] [1,3] thiazoles (3a-e) and imidazo [2,1-b] [1,3] benzothiazoles (5a-h), have been synthesized. The structure of newly synthesized compounds was characterized by NMR, mass spectral data and elemental analyses. The antimicrobial activity was carried out against various Gram-positive, Gram-negative bacteria and fungi. Some of the compounds exhibited moderate to good activity as compared to the standard drugs. Preliminary structure activity observations revealed that the presence of fluoro, chloro, cyano or nitro functional groups in the synthesized compounds enhanced the antimicrobial activity significantly compared to other substituents. Further, the synthesized compounds were screened for antioxidant (DPPH method) property and compounds 3a and 5a showed promising scavenging activity with DPPH free radicals.
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